Edwin H. Murty Professor of Engineering, Washington University
Professor of Biomedical Engineering, Washington University
Director of the Center for Biological Systems Engineering, Washington University
Member of the Hope Center for Neurological Disorders, Washington University School of Medicine
Contact: pappu@wustl.edu
Phone: (314) 935-7958
Office: Brauer Hall, Room 2015a
1998 - 2001: Postdoctoral Training, Johns Hopkins University School of Medicine
1996 - 1998: Postdoctoral Training, Washington University School of Medicine
1996: Ph.D. Biological Physics, Tufts University, John F. Burlingame Graduate Fellowship
1989: B.Sc. Physics, Electronics, Mathematics, St. Joseph's College, Bangalore India, National Merit Scholarship
2012 - current: Director of the Center for Biological Systems Engineering, Washington Universit
2011 - current: Professor of Biomedical Engineering, Washington University
2007 - current: Member of the Hope Center for Neurological Disorders, Washington University School of Medicine
2007 - 2010: Associate Professor of Biomedical Engineering, Washington University
2001 - 2010: Member, Center for Computational Biology, Washington University
2001 - 2007: Assistant Professor of Biomedical Engineering, Washington University
Contact: ammonposey@wustl.edu
Ph.D. in Molecular Biophysics, Johns Hopkins University (2014)
Research:
Experimental approaches to study polyglutamine-mediated aggregation; development and deployment of novel experimental methods to study protein phase behavior and order-disorder transitions of disordered proteins
Contact: jeongmochoi@wustl.edu
Ph.D. in Chemistry, Harvard University (2016)
Research:
Development of the second generation of the ABSINTH forcefield, molecular theory of phase transitions, and the development of multiscale, multiresolution methods for modeling protein phase behavior with directional interactions and conformational transitions.
Contact: martinfossat@wustl.edu
Ph.D. in Physics, Université de Montpellier (2016)
Research:
Machine-learning methods for comparing simulated ensembles to experimentally derived ensembles for IDPs, atomistic modeling of multivalent proteins with disordered linkers and bristles, and modeling functional specificity of IDPs.
Contact: alex.holehouse@wustl.edu
Ph.D. in Biophysics, Washington University in St. Louis (2017)
MSc in Computer Science, Imperial College London (2011)
Research:
Biophysics of phase separation, the impact of multisite phosphorylation on IDP conformations and functions, sequence-to-fitness relationships in IDPs, and the development of multiscale, multiresolution methods to enable the prediction of sequence-specific phase diagrams from numerical simulations of IDP sequences.
Teaching material
IDP State Letter (Monthly IDP Newsletter)
Homepage
Contact: sangeunjee@wustl.edu
Ph.D. in Chemical Engineering, Carnegie Mellon University/Georgia Institute of Technology (2010)
Postdoctoral Work with Prof. Seung Soon Jang, Georgia Institute of Technology
Research:
Multiscale modeling of sequence-specific fibril formation computationally driven design of peptide- and protein-based biomaterials with specified mechanical properties, hysteresis profiles, and network attributes.
Contact: kiersten.ruff@wustl.edu
Ph.D. in Computational and Systems Biology, Washington University in St. Louis (2017)
Research:
Molecular and cellular biophysics properties of polar tracts and their impact on cellular homeostasis and functions; Advanced machine-learning methods for modeling IDPs, linkage processes in phase separation, and mechanisms of aggregation and phase separation.
Contact: mcohan@wustl.edu
Ph.D. Student in Biomedical Engineering
BS in Chemical and Biomolecular Engineering, Johns Hopkins University (2015)
Research:
Experimental characterization and modeling of polymerization of bristled GTPases and their impact on cellular phenotypes; Experimental characterization of aggregation and phase separation in systems with polyglutamine tracts.
Contact: jared.lalmansingh@wustl.edu
Ph.D. Student in Physics
MS in Physics, Texas A&M University-Commerce (2015)
BS in Physics, South Carolina State University (2011)
Research:
Molecular and mesoscale descriptions of conformations, interactions, and self-assembly of globular proteins with intrinsically disordered bristles; the biophysics and biomimicry of neurofilament sidearms; and implementation of efficient algorithms and software pipelines for molecular and mesoscale simulations;
Contact: dknatara@wustl.edu
M.D. Student
MPhil in Clinical Sciences, University of Cambridge (2016)
BS in Biomedical Engineering and Biology, Georgia Institute of Technology (2015)
Research:
Experiments aided by high-throughput techniques and molecular and cell biology tools for characterization of aggregation and phase separation in disease-related proteins.
Contact: m.richardson@wustl.edu
BS in Biomedical Engineering, Washington University in St. Louis (2017)
Research:
The evolution of IDPs and covariation of SLiMs and their contexts in protein interaction networks
Senior at Washington University in St. Louis (BME)
Research:
Molecular origins of protein-protein interactions in low complexity sequences
Ph.D. in Physics
April 2017
Ph.D. in Computational and Systems Biology
May 2013
Ph.D. in Computational and Molecular Biophysics
August 2012
Ph.D. in Biomedical Engineering
June 2011
B.S. / M.S. in Biomedical Engineering
May 2011
Ph.D. in Biomedical Engineering
December 2009
M.S. in Molecular Biophysics
May 2009
Ph.D. in Molecular Biophysics
June 2009
Ph.D. in Molecular Biophysics
April 2009
Ph.D. in Biomedical Engineering
December 2007
Lab Member: Oct 2015 - June 2016
Lab Member: February 2012 - October 2014
Lab Member: April 2012 - May 2013
Lab Member: November 2010 - August 2011
Lab Member: June 2006 - December 2009
Lab Member: September 2004 - February 2008
Lab Member: September 2002 - June 2004
Lab Member: August 2009 - December 2010
Visting graduate student from the Institute of Advanced Chemistry of Catalonia of the Spanish Council for Scientific Research (IQAC-CSIC), Barcelona, Spain
Fall 2016
Summer 2013, Spring/Summer 2015, Spring 2017
Fall 2016, Spring 2017
Summer 2015
Summer 2014
Summer 2012, summer 2013 - summer 2014
Summer 2012
Summer 2012
Spring 2012
Summer 2011 and 2012
Summer 2011
Summer 2011
Fall 2010 - Spring 2011
Spring 2011
Summer 2009 and 2010
Fall 2009 - Spring 2010
Summer 2009
Summer 2008
Summer 2007
Fall 2004 - Spring 2005
Fall 2004 - Spring 2005