Gene K. Beare Distinguished Professor of Engineering, McKelvey School of Engineering, Washington University in St. Louis
Professor of Biomedical Engineering, Washington University in St. Louis
Director, Center for Biomolecular Condensates (CBC), Washington University in St. Louis
Member of the Hope Center for Neurological Disorders, Washington University School of Medicine
Contact: pappu@wustl.edu
Phone: (314) 935-7958
Office: Brauer Hall, Room 2015a
| July 2022 - current | Director, Center for Biomolecular Condensates (CBC), James McKelvey School of Engineering, Washington University in St. Louis | |||
| September 2021 - current | Gene K. Beare Distinguished Professor of Engineering, McKelvey School of Engineering, Washington University in St. Louis | |||
| January 2018 - June 2022 | Director, Center for Science & Engineering of Living Systems (CSELS), James McKelvey School of Engineering, Washington University in St. Louis, Washington University in St. Louis | |||
| March 2015 - August 2021 | Edwin H. Murty Professor of Engineering, McKelvey School of Engineering, Washington University in St. Louis | |||
| September 2012 - December 2018 | Director, Center for Biological Systems Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences | |||
| January 2013 - January 2018 | Co-Director, Center for High Performance Computing, Washington University in St. Louis | |||
| January 2011 - current | Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences | |||
| March 2007 - current | Member, Hope Center for Neurodegenerative Disorders, Washington University School of Medicine | |||
| July 2007 - December 2010 | Associate Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences; Adjunct Associate Professor, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine | |||
| February 2009 - August 2010 | Director, Center for Computational Biology, Washington University School of Medicine | |||
| May 2002 - August 2010 | Member, Center for Computational Biology, Washington University School of Medicine | |||
| September 2001 - June 2007 | Assistant Professor, Department of Biomedical Engineering, Washington University in St. Louis | |||
1998 - 2001: Postdoctoral Training, Johns Hopkins University School of Medicine
1996 - 1998: Postdoctoral Training, Washington University School of Medicine
1996: Ph.D. Biological Physics, Tufts University, John F. Burlingame Graduate Fellowship
1989: B.Sc. Physics, Electronics, Mathematics, St. Joseph's College, Bangalore India, National Merit Scholarship
July 2022 - current: Director, Center for Biomolecular Condensates (CBC), James McKelvey School of Engineering, Washington University in St. Louis
September 2021 – current: Gene K. Beare Distinguished Professor of Engineering, McKelvey School of Engineering, Washington University in St. Louis
July 2018 - June 2022: Director, Center for Science & Engineering of Living Systems (CSELS), James McKelvey School of Engineering, Washington University in St. Louis
March 2015 – current: Edwin H. Murty Professor of Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
September 2012 – December 2018: Director, Center for Biological Systems Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
January 2013 – January 2018: Co-Director, Center for High Performance Computing, Washington University in St. Louis
January 2011 – current: Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
March 2007 – current: Member, Hope Center for Neurodegenerative Disorders, Washington University School of Medicine
July 2007 – December 2010: Associate Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences; Adjunct Associate Professor, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine
February 2009 – August 2010: Director, Center for Computational Biology, Washington University School of Medicine
May 2002 – August 2010: Member, Center for Computational Biology, Washington University School of Medicine
September 2001 – June 2007: Assistant Professor, Department of Biomedical Engineering, Washington University in St. Louis
Contact: martinfossat@wustl.edu
Ph.D. in Physics, Université de Montpellier (2016)
Research:
Efficient and accurate modeling of charge regulation in IDPs; Effects of pH on responsive phase transitions of disordered proteins; Modeling post-translational modifications in IDPs.
Contact: ammonposey@wustl.edu
Ph.D. in Molecular Biophysics, Johns Hopkins University (2014)
Research:
Experimental approaches to study polyglutamine-mediated aggregation; development and deployment of novel experimental methods to study protein phase behavior and order-disorder transitions of disordered proteins
Contact: kiersten.ruff@wustl.edu
Ph.D. in Computational and Systems Biology, Washington University in St. Louis (2017)
Research:
Molecular and cellular biophysics properties of polar tracts and their impact on cellular homeostasis and functions; Advanced machine-learning methods for modeling IDPs, linkage processes in phase separation, and mechanisms of aggregation and phase separation.
Contact: cgaurav@wustl.edu
Ph.D. in Chemical and Biomolecular Engineering, The University of Tennessee, Knoxville (2022)
Research:
Thermodynamics and dynamics of phase transitions of associative polymers in multicomponent mixtures; Understanding the contributions of condensate interfaces & interiors to regulation of biochemical reactions.
Contact: samuel.cohen@wustl.edu
Ph.D. in Physical Chemistry, University of Maryland, College Park (2021)
Research:
Postdoc on the T32 training grant in regenerative medicine working on the structures and dynamics of network fluids in the context of biomolecular condensates, the physics of aging in viscoelastic materials, and adaptation and improvement of complex coacervation formalisms for describing nuclear bodies.
Contact: dar@wustl.edu
BS in Physics (minor in Math and Scientific Computing), Kenyon College (2016)
PhD in Physics, Washington University in St. Louis (July, 2022)
Research:
Thermodynamics and dynamics of phase separation of multivalent proteins; Interplay between driven and spontaneous processes in intracellular phase transitions.
Contact: matthewking@wustl.edu
Ph.D. in Molecular Biology, Princeton University (2019)
Research:
Ruth L. Kirschstein NRSA (F32) Postdoctoral Fellow who is working on biochemical reconstitutions of fibrillar centers and dense fibrillar components of nucleoli to uncover how the molecular handoff model is applicable for describing rRNA fluxes within nucleoli; Design of novel thermoresponsive materials based on polyampholytes.
Contact: mshinn@wustl.edu
Ph.D. in Physics (BioPhysics), Washington University in St. Louis (2020).
Research:
CBC Postdoctoral Fellow in the McKelvey School of Engineering who is working on the evolution of IDRs, computational modeling and experimental reconstitutions of bacterial condensates and nuclear speckles, and the development of novel methods for investigating the impact of evolved sequence fingerprints on IDR functions.
Contact: xzengae@wustl.edu
Ph.D. in Chemistry, Hong Kong University of Science and Technology (HKUST) (2017)
Research:
Multiscale modeling of thermoresponsive phase behavior in intrinsically disordered protein polymers; De novo design of thermoresponsive IDPs; Thermoresponsive phase separation of protein and RNA mixtures.
Contact: minafarag@wustl.edu
BME Ph.D. student in the Medical Scientist Training Program
BS in Biophysics and Mathematics, Johns Hopkins University (2015)
Research:
Uncovering the molecular grammar underlying the sequence-encoded driving forces for percolation and phase separation in seemingly low complexity IDPs; Development of novel formalisms to connect molecular and mesoscale descriptions of condensate interfaces.
Contact: g.nikita@wustl.edu
Ph.D. Student in Division of Biology and Biomedical Sciences
Integrated BS-MS (Biology), Indian Institute of Science Education and Research Pune, India (2022)
Research:
Charge regulation, charge renormalization, and their effects on phase transitions disordered proteins.
Contact: lin.andrew@wustl.edu
Ph.D. Student in Plant and Microbial Biosciences
BS Microbial Biology, University of California-Berkeley (2015)
Research:
Experimental characterization of the impact of protein-RNA and RNA-RNA interactions on the phase behavior of archetypal RNP granules
Contact: liu.vicky@wustl.edu
Ph.D. Student in Biomedical Engineering
BS Physics (dual-major in Physics and Quantitative Sciences), Emory University (2022)
Research:
Evolution of stickers and spacers and the driving forces for phase separation coupled to percolation in linear multivalent proteins.
Contact: a.pant@wustl.edu
Ph.D. Student, Yoram Rudy Graduate Fellow, in Biomedical Engineering
M.Tech in Polymers and Biosystems Engineering, Indian Institute of Technology Hyderabad (2022)
B.Tech in Biotechnology, Amity University (2020)
Research:
Principles of phase transitions in protein-RNA mixtures mimicking nuclear and cytosolic bodies.
Contact: jared.lalmansingh@wustl.edu
Ph.D. in Physics, Washington University in St. Louis (2021)
MS in Physics, Texas A&M University-Commerce (2015)
BS in Physics, South Carolina State University (2011)
If you are interested in rotating within the lab, please contact Rohit Pappu (pappu@wustl.edu) for more details.
Ph.D. in Biomedical Engineering
December 2020
Ph.D. in Physics
April 2017
Ph.D. in BioPhysics
May 2017
Ph.D. in Computational and Systems Biology
May 2013
Ph.D. in Computational and Molecular Biophysics
August 2012
Ph.D. in Biomedical Engineering
June 2011
B.S. / M.S. in Biomedical Engineering
May 2011
Ph.D. in Biomedical Engineering
December 2009
M.S. in Molecular Biophysics
May 2009
Ph.D. in Molecular Biophysics
June 2009
Ph.D. in Molecular Biophysics
April 2009
Ph.D. in Biomedical Engineering
December 2007
Lab Member: August 2018 - August 2019
Lab Member: August 2017 - June 2018
Lab Member: September 2020 - June 2021
Lab Member: January 2015 - December 2020
Lab Member: May 2017 - December 2019
Lab Member: August 2016 - April 2019
Lab Member: Oct 2016 - Nov 2017
Lab Member: Oct 2015 - June 2016
Lab Member: February 2012 - October 2014
Lab Member: April 2012 - May 2013
Lab Member: November 2010 - August 2011
Lab Member: June 2006 - December 2009
Lab Member: September 2004 - February 2008
Lab Member: September 2002 - June 2004
Lab Member: August 2009 - December 2010
Lab Member: August 2018 - October 2022
Visting graduate student from the Institute of Advanced Chemistry of Catalonia of the Spanish Council for Scientific Research (IQAC-CSIC), Barcelona, Spain
Fall 2016
Summer 2021 - Spring 2022
Summer 2020 - Spring 2022
Summer 2019, Summer 2020
Summer 2018 - Spring 2020
Summer 2019 - Spring 2020
Summer 2017 - Summer 2018
Summer 2013, Spring/Summer 2015, Spring 2017
Fall 2016, Spring 2017
Summer 2015
Summer 2014
Summer 2012, Summer 2013 - Summer 2014
Summer 2012
Summer 2012
Spring 2012
Summer 2011 and 2012
Summer 2011
Summer 2011
Fall 2010 - Spring 2011
Spring 2011
Summer 2009 and 2010
Fall 2009 - Spring 2010
Summer 2009
Summer 2008
Summer 2007
Fall 2004 - Spring 2005
Fall 2004 - Spring 2005
