Edwin H. Murty Professor of Engineering, Washington University
Professor of Biomedical Engineering, Washington University
Director of the Center for Biological Systems Engineering, Washington University
Member of the Hope Center for Neurological Disorders, Washington University School of Medicine
Contact: pappu@wustl.edu
Phone: (314) 935-7958
Office: Brauer Hall, Room 2015a
1998 - 2001: Postdoctoral Training, Johns Hopkins University School of Medicine
1996 - 1998: Postdoctoral Training, Washington University School of Medicine
1996: Ph.D. Biological Physics, Tufts University, John F. Burlingame Graduate Fellowship
1989: B.Sc. Physics, Electronics, Mathematics, St. Joseph's College, Bangalore India, National Merit Scholarship
January 2019 - current: Director of CSELS, Center for the Science and Engineering of Living Systems, Washington University in St. Louis
March 2015 – current: Edwin H. Murty Professor of Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
September 2012 – December 2018: Director, Center for Biological Systems Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
January 2013 – January 2018: Co-Director, Center for High Performance Computing, Washington University in St. Louis
January 2011 – current: Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
March 2007 – current: Member, Hope Center for Neurodegenerative Disorders, Washington University School of Medicine
July 2007 – December 2010: Associate Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences; Adjunct Associate Professor, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine
February 2009 – August 2010: Director, Center for Computational Biology, Washington University School of Medicine
May 2002 – August 2010: Member, Center for Computational Biology, Washington University School of Medicine
September 2001 – June 2007: Assistant Professor, Department of Biomedical Engineering, Washington University in St. Louis
Contact: ammonposey@wustl.edu
Ph.D. in Molecular Biophysics, Johns Hopkins University (2014)
Research:
Experimental approaches to study polyglutamine-mediated aggregation; development and deployment of novel experimental methods to study protein phase behavior and order-disorder transitions of disordered proteins
Contact: jeongmochoi@wustl.edu
Ph.D. in Chemistry, Harvard University (2016)
Research:
Development of the second generation of the ABSINTH forcefield, molecular theory of phase transitions, and the development of multiscale, multiresolution methods for modeling protein phase behavior with directional interactions and conformational transitions.
Contact: martinfossat@wustl.edu
Ph.D. in Physics, Université de Montpellier (2016)
Research:
Efficient and accurate modeling of charge regulation in IDPs; Machine-learning methods for comparing simulated ensembles to experimentally derived ensembles for IDPs; and modeling post-translational modifications in IDPs.
Contact: alex.holehouse@wustl.edu
Ph.D. in Biophysics, Washington University in St. Louis (2017)
MSc in Computer Science, Imperial College London (2011)
Research:
Biophysics of phase separation, the impact of multisite phosphorylation on IDP conformations and functions, sequence-to-fitness relationships in IDPs, and the development of multiscale, multiresolution methods to enable the prediction of sequence-specific phase diagrams from numerical simulations of IDP sequences.
Teaching material
IDP State Letter (Monthly IDP Newsletter)
Homepage
Contact: kiersten.ruff@wustl.edu
Ph.D. in Computational and Systems Biology, Washington University in St. Louis (2017)
Research:
Molecular and cellular biophysics properties of polar tracts and their impact on cellular homeostasis and functions; Advanced machine-learning methods for modeling IDPs, linkage processes in phase separation, and mechanisms of aggregation and phase separation.
Contact: xzengae@wustl.edu
Ph.D. in Chemistry, Hong Kong University of Science and Technology (HKUST) (2017)
Research:
Multiscale modeling of thermoresponsive phase behavior in intrinsically disordered protein polymers; De novo design of thermoresponsive IDPPs; Interplay between the glass transition and coil-to-globule transition of polyamides; Context dependencies of free energies of solvation.
Contact: mcohan@wustl.edu
Ph.D. Student in Biomedical Engineering
BS in Chemical and Biomolecular Engineering, Johns Hopkins University (2015)
Research:
Experimental characterization and modeling of FtsZ polymerization; Sequence features of disordered tails that control bacterial phenotypes; Measures for quantifying sequence-to-conformation relationships of IDRs.
Contact: dar@wustl.edu
Ph.D. Student in Physics
BS in Physics (minor in Math and Scientific Computing), Kenyon College (2016)
Research:
Thermodynamics and dynamics of phase separation of multivalent proteins; Interplay between driven and spontaneous processes in intracellular phase transitions
Contact: minafarag@wustl.edu
Ph.D rotation student in the Medical Scientist Training Program
BS in Biophysics and Mathematics, Johns Hopkins University (2015)
Research:
Field theoretic models for dynamics of phase separation
Contact: jared.lalmansingh@wustl.edu
Ph.D. Student in Physics
MS in Physics, Texas A&M University-Commerce (2015)
BS in Physics, South Carolina State University (2011)
Research:
Comparing simulation paradigms for IDPs; Effects of n-nary sequence patterns on conformations of IDPs; CAMPARI in Julia
Contact: lin.andrew@wustl.edu
Ph.D. Student in Plant and Microbial Biosciences
BS Microbial Biology, University of California-Berkeley (2015)
Research:
Experimental characterization of biological phase behavior
Ph.D rotation student in Biomedical Engineering
BS in Biomedical Engineering and Mathematics, Northwestern University (2018)
Research:
Patchy colloid models of self-assembly
Contact: g.ginell@wustl.edu
BA in Biochemistry and Molecular Biology, Cornell College (2018)
Research:
Computational and experimental method development to quantify disorder
Contact: cakornacki@wustl.edu
B.S. in Biology, Webster University (2013)
M.S. in Biochemistry and Molecular Biophysics, Kansas State Univesity (2016)
Ph.D. in Systems Biology, Harvard University (2015)
Research:
The relationship between sequence and function in disordered transactivation domains
Junior at Washington University in St. Louis (BME and Educational Studies)
Research:
Experiments to determine the role of disordered tails in FtsZ assembly and phase behavior
M.D. (anticipated May 2020)
Ph.D. in Physics
April 2017
Ph.D. in Computational and Systems Biology
May 2013
Ph.D. in Computational and Molecular Biophysics
August 2012
Ph.D. in Biomedical Engineering
June 2011
B.S. / M.S. in Biomedical Engineering
May 2011
Ph.D. in Biomedical Engineering
December 2009
M.S. in Molecular Biophysics
May 2009
Ph.D. in Molecular Biophysics
June 2009
Ph.D. in Molecular Biophysics
April 2009
Ph.D. in Biomedical Engineering
December 2007
Lab Member: August 2017 - June 2018
Lab Member: Oct 2016 - Nov 2017
Lab Member: Oct 2015 - June 2016
Lab Member: February 2012 - October 2014
Lab Member: April 2012 - May 2013
Lab Member: November 2010 - August 2011
Lab Member: June 2006 - December 2009
Lab Member: September 2004 - February 2008
Lab Member: September 2002 - June 2004
Lab Member: August 2009 - December 2010
Visting graduate student from the Institute of Advanced Chemistry of Catalonia of the Spanish Council for Scientific Research (IQAC-CSIC), Barcelona, Spain
Fall 2016
Summer 2017 - Summer 2018
Summer 2013, Spring/Summer 2015, Spring 2017
Fall 2016, Spring 2017
Summer 2015
Summer 2014
Summer 2012, Summer 2013 - Summer 2014
Summer 2012
Summer 2012
Spring 2012
Summer 2011 and 2012
Summer 2011
Summer 2011
Fall 2010 - Spring 2011
Spring 2011
Summer 2009 and 2010
Fall 2009 - Spring 2010
Summer 2009
Summer 2008
Summer 2007
Fall 2004 - Spring 2005
Fall 2004 - Spring 2005